What is in Advanced Mitochondrial Formula?

Advanced Mitochondrial Formula lists Coenzyme Q10, Acetyl-L-Carnitine, Alpha-Lipoic Acid, Resveratrol and Bioperine®. The manufacturer does not publish per-serving amounts, so the ingredient names are known and the quantities are not.

Does CoQ10 (Ubiquinol) actually work?

Coenzyme Q10 is an antioxidant fat-soluble compound found in every cell, with the highest concentrations in tissues with high energy demand: heart, kidneys, liver, and brain. Studies generally use around 100 mg/day with fat. Whether this particular product supplies that much is not something the label lets you check.

Are there side effects?

Most people tolerate it. The cautions worth knowing come from the individual ingredients, listed in the safety section on this page, and anyone on prescription medication should run the ingredient list past a pharmacist first.

Is Advanced Mitochondrial Formula worth the money?

It depends what you are comparing it against. Because the amounts are not published, you are paying for a named ingredient list rather than a verified dose. If that matters to you, a formula that publishes its panel is the better buy at the same price.

How long before it does anything?

Supplements in general health are generally taken for weeks rather than days, and the manufacturers themselves usually suggest two to three months. Treat anything promising a result in a week with suspicion.

Updated October 2026Expert Reviewed

Advanced Mitochondrial Formula Review 2026What Is Inside, and Who It Suits

Name: Advanced Mitochondrial Formula
Brand: Advanced Bionutritionals
Price: 45 USD
Availability: InStock
Rating: 7.2 (1 reviews)

by Advanced Bionutritionals

|Medically Reviewed by Editorial Team

Advanced Mitochondrial Formula is a two-capsule "energy" supplement from Advanced Bionutritionals, LLC of Norcross, Georgia, sold through Digistore24 for $66.65 to $79.95 a bottle. It is endorsed by Dr. Frank Shallenberger, who the page says is paid for formulating and endorsing it.

Adults wanting a multi-ingredient energy formula with a long refund window

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On this page

Score Breakdown
Summary
Dosage Analysis
Quality & Testing
Pros & Cons
Who Is This For?
Value for Money
Side Effects & Safety
Final Verdict
FAQ

Score Breakdown

3.6

/ 5

Ingredients

7.8

Dosage

6.5

Value

7.3

Transparency

6.5

Brand

7.0

Pros & Cons

Pros

All 11 doses published
Named US company with a phone number
90-day refund, empty bottles accepted

Cons

'3,000% NAD in 30 minutes' claim unsupported
PQQ at a quarter of the trial dose

Who Is This For?

Recommended For:

Adults who want a single multi-ingredient "energy" capsule from an identifiable company with a long refund window, and who accept that the individual doses are low and the NAD claim is not supported by the research we found.

Not Recommended For:

People taking warfarin or insulin (CoQ10 may interact, according to the NCCIH), anyone on regular medication without checking, since black pepper extract can change how some drugs are cleared, people expecting a measurable energy change from the headline claims, and anyone with persistent fatigue that has not been checked by a doctor.

Summary

What is in it, per 2 capsules: niacinamide 200 mg, D-ribose 250 mg, acetyl-L-carnitine 190 mg, curcumin 180 mg, quercetin 65 mg, CoQ10 50 mg, R-alpha lipoic acid 50 mg, magnesium 45 mg, resveratrol 25 mg, black pepper extract 10 mg and PQQ 5 mg. Every dose is published, which is to its credit.

What we found when we checked the doses:

"Raise your NAD levels by 3,000% in 30 minutes." The only human study of this niacinamide and D-ribose pairing used about seven times the dose for 7 days and found one NAD-related measure up 27%. We found no source for 3,000%.
PQQ is at a quarter of the dose used in the memory trials.
Curcumin is sold as improving VO2 max, but a trial at 2 g a day, eleven times this dose, found no effect.

It costs $2.22 to $2.67 a day, and has a 90-day money-back guarantee that accepts empty bottles.

Ingredient Breakdown

Eleven ingredients, all dosed. The main ones and their best human evidence:

Niacinamide 200 mg + D-ribose 250 mg (the "NAD boosters"). A small crossover trial of a nicotinamide and D-ribose product at 3,040 mg a day for 7 days raised one NAD-related measure (NADP+) by 27% compared with placebo. Fatigue improved only compared with baseline, not with placebo, and the lead authors worked for the ingredient supplier. D-ribose alone was tested at 15 g a day in an uncontrolled study, 60 times this amount.
CoQ10, 50 mg. A meta-analysis of 13 trials found CoQ10 reduced fatigue, with larger doses working better, but the effect was not significant for multi-ingredient formulas like this one.
PQQ, 5 mg. Two 12-week trials at 20 to 21.5 mg a day found improvements in memory or cognition; both were linked to PQQ manufacturers.
Curcumin, 180 mg (95% curcuminoids). The page says it improves VO2 max "in a matter of weeks". A 6-week trial in 30 runners at 2 g a day found no significant effect on VO2 max.
Black pepper extract (BioPerine), 10 mg. The "20-fold" absorption figure comes from a study that gave 2 g of curcumin with 20 mg of piperine at once.
Acetyl-L-carnitine 190 mg, R-alpha lipoic acid 50 mg, quercetin 65 mg, resveratrol 25 mg, magnesium 45 mg. We did not find fatigue trials matching these doses.

The company's Pep Tonic takes a similar approach with NMN and spermidine. For the wider NAD debate, see our guide on whether NAD supplements slow ageing.

What Advanced Mitochondrial Formula does not tell you

No amounts published

Advanced Mitochondrial Formula names its ingredients but publishes no amount for any of them, so there is nothing here to check against the research.

Amounts are taken from the manufacturer’s own supplement facts panel. Where a label states a standardisation, the active fraction is what we compare, because the active is what the trials measured.

Dosage Analysis

Our Dose Check compares each label amount with the dose in the best human study.

Niacinamide + D-ribose: 450 mg together vs 3,040 mg a day. About 15%, in a 7-day, supplier-run pilot.
D-ribose alone: 250 mg vs 15 g a day. About 1/60, in an uncontrolled study.
CoQ10: 50 mg, a low dose. The fatigue benefit grew with dose and was not significant in combination products.
PQQ: 5 mg vs 20 to 21.5 mg a day. A quarter.
Curcumin: about 171 mg of curcuminoids vs 2 g a day, which did not change VO2 max. About a twelfth, of a dose that failed.

The product takes the "many ingredients, low doses" approach: about 1 g of actives a day spread across 11 compounds. Two capsules a day; a bottle lasts 30 days.

Quality & Testing

Our Transparency Score checks five things any buyer can verify. Advanced Mitochondrial Formula scores 3 out of 5.

Label with doses: yes. All 11 ingredients are dosed on the label.
Identifiable company: yes. Advanced Bionutritionals, LLC, 5305 Oakbrook Parkway, Norcross, Georgia, with a phone number.
Refund terms in writing: yes. 90 days, empty bottles accepted.
Independent testing shown: no.
Study on the finished product: no.

Inconsistencies on the sales page: the page counts 11 nutrients while its FAQ says 10; the label calls BioPerine a Piper longum extract, although BioPerine is marketed as black pepper (Piper nigrum); and the refund text says both that shipping is refunded and that you pay return shipping.

What customers say about the company: on PissedConsumer, a complaints site, Advanced Bionutritionals averages 1.6 out of 5 from 75 reviews, mainly about refunds and auto-ship. We found no reviews specific to this product.

Correction. An earlier version of this review said no amounts were published, listed 5 ingredients including ubiquinol, and described EU manufacture and a $1.50 daily cost. The label lists 11 dosed ingredients and the real cost is $2.22 to $2.67 a day. We have corrected it.

Value for Money

Prices on the official page when we checked in September 2026:

1 bottle: $79.95, about $2.67 a day.
3 bottles: $214.95 ($71.65 each), free shipping, about $2.39 a day.
6 bottles: $399.90 ($66.65 each), free shipping, about $2.22 a day.

The product is sold in US dollars only.

Refunds. The page offers a "Down-to-the-Last-Pill" guarantee: return your bottles, "even your empty bottles", within 90 days. One part of the page says shipping is refunded, another says you pay return shipping. Digistore24, the reseller, also accepts refund requests, within its 180-day maximum. Check your order confirmation for any subscription, given the auto-ship complaints about the company.

Side Effects & Safety

CoQ10: mild insomnia or digestive upset are possible; it may interact with warfarin and insulin (NCCIH).
Niacinamide 200 mg: well above the daily requirement. We could not verify the current US upper-limit guidance for niacinamide, so ask a pharmacist if you take other B-vitamin products.
Black pepper extract: can raise blood levels of some medicines.

There is no clinical study on Advanced Mitochondrial Formula itself.

Final Verdict

Our Verdict

3.6/5

Advanced Mitochondrial Formula is honest about its label and its company, and generous on refunds. It is less honest about what the label can do: its NAD claim has no source we could find, and most ingredients sit at a fraction of the doses tested, several of which did not work even at full strength. It is a reasonable experiment with a good refund if you want one; do not expect the "rocket fuel" the page describes. Sources: [Xue et al. 2022, nicotinamide and D-ribose pilot](https://pubmed.ncbi.nlm.nih.gov/35684021/) · [Tsai et al. 2022, CoQ10 and fatigue meta-analysis](https://pubmed.ncbi.nlm.nih.gov/36091835/) · [Tamakoshi et al. 2023, PQQ and memory](https://pubmed.ncbi.nlm.nih.gov/36807425/) · [Bańkowski et al. 2022, curcumin and VO2 max](https://pubmed.ncbi.nlm.nih.gov/36125053/) · [NCCIH, CoQ10](https://www.nccih.nih.gov/health/coenzyme-q10) · Advanced Mitochondrial Formula label and sales page, checked 28 September 2026.

Best For:

Adults wanting a multi-ingredient energy formula with a long refund window

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Frequently Asked Questions

Medical Disclaimer

The content on this page is for informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult your physician or qualified healthcare provider before starting any new supplement regimen. Individual results may vary.