Urinary supplements target two main concerns: urinary tract infection (UTI) prevention and benign bladder symptoms. Evidence quality varies significantly by ingredient.
- D-Mannose (2 g/day for prevention, 3 g 2-3x/day acute): Strong evidence for UTI prevention by preventing E. coli adhesion to bladder walls.
- Cranberry (36 mg proanthocyanidins/day): Modest evidence for UTI prevention when using PACs-standardized extract.
- Probiotics β Lactobacillus rhamnosus GR-1, L. reuteri RC-14: Evidence for recurrent UTI prevention in women.
- Buchu and uva ursi: Traditional use; modest clinical evidence for acute symptom relief.
- Vitamin C (500β1000 mg/day): Acidifies urine slightly; modest support.
- Cranberry products without standardized PAC content (most juice has insufficient PACs)
- Uva ursi for long-term use (hepatotoxicity risk after 2+ weeks)
- D-Mannose marketed as UTI treatment (it's for prevention and early symptoms, not established infections)
- Proprietary "bladder support" blends with undisclosed doses
Extract standardization (especially cranberry PAC content), D-mannose purity, probiotic strain specificity (generic Lactobacillus won't do), and clear labeling that symptoms persisting beyond 24β48 hours need antibiotics.